In Friedman and Magidor - The Number of Normal Measures, the authors use a nonstationary support iteration of posets, rather than the more customary countable or Easton support iterations: conditions $p$ are allowed where $\operatorname{supp}(p) \cap \lambda$ is nonstationary in $\lambda$ for all inaccessible $\lambda \leq \kappa$. Thus, all conditions which are allowed in an ESI are allowed here, and then some.
I unfortunately haven't had the opportunity to inspect the details of this paper. Does anybody know of other applications of nonstationary support iterations and what makes them substantially different from ESIs?