if the node is down the data can be sent to the replica, depending on your replication factor and of your consistency level, your request might fail, if the number of acknowledgment required are not met. Of course, depending on your replication factor and CL, read request will be served or not. depending on how many replicas you have and how many acknowledgment you expect.
There is a cool mechanism used to help this kind of cases, it is hinted handoff. To make it simple if you have replication factor set to 1, and the node responsible of the data is down, the coordinator will store the data for him for a while ( hours) then when the node will be up again the coordinator will send him the missed data.
To make it more simple, it is like a neighbor taking your mail while your not around. This is made for small failure failures and not long one. it won't be cool if the neighbor will take the post mail for years.
Here is a link that explain how hints work
https://www.datastax.com/blog/2011/05/understanding-hinted-handoff-cassandra-08
I hope this help !