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Yatin Mundkur liked thisYatin Mundkur liked thisPrivate market and venture ecosystem insights to help founders, investors, and employees understand market conditions and make informed decisions.
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Yatin Mundkur liked thisAnother trend that will come and go.Yatin Mundkur liked thisThe AI Career Everyone Is Naming, but Almost Nobody Understands I’ve been getting more questions lately from people who have taken my AI courses about how to become a forward-deployed engineer. It’s an interesting question because the title is suddenly everywhere, but the meaning has become increasingly muddy. The term originally came out of Palantir, where it described engineers embedded close to the customer, solving real operational problems in the field. Since then, consulting firms, hyperscalers, and technology companies have stretched the term to mean almost anything: solution architect, sales engineer, platform specialist, implementation consultant, or traditional engineer with a customer-facing role. That misses the real point. A true forward deployed engineer is both a planner and a doer. This person sits at the intersection of business problems, AI architecture, economics, and execution. They are not just there to build what someone else already decided to buy. They are there to understand the business issue, define the use case, calculate the ROI, evaluate the technology options, and help deploy the solution that is closest to optimal. That distinction matters more in AI than it has in almost any previous technology wave. In most enterprise AI projects, many technology configurations will work. You can use different models, clouds, data platforms, orchestration layers, agentic architectures, monolithic architectures, and integration approaches. The problem is not finding something that functions. The problem is finding the approach that solves the business problem without costing 20 or 30 times more than it should. This is where many training programs fall short. They teach one path, usually aligned to one vendor or one platform. That may create useful tactical skills, but it does not create objective AI problem solvers. Too many engineers become one-track ponies, seeing every business issue through the lens of AWS, Google, Microsoft, Nvidia, or whatever ecosystem they know best. Forward deployed engineers need to be different. They need enough breadth to understand the AI technology landscape, enough business sense to know what problem is worth solving, enough financial discipline to defend the ROI, and enough engineering depth to get the solution into production. They also need to be team players. This is not a lone-wolf role. C-level executives, business leaders, analysts, operations teams, finance, and technical teams all need to be part of the process. AI deployments are business change programs as much as they are technology projects. This role matters because enterprises don't need more AI experiments. They need people who can connect AI to measurable business value and make objective decisions about what to deploy. That’s the gap the forward-deployed engineer should fill. And if we define the role correctly, it may become one of the most valuable careers in enterprise AI.Forward Deployed Engineer: The AI Career That No Training Course Will Teach YouForward Deployed Engineer: The AI Career That No Training Course Will Teach YouDavid Linthicum
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Yatin Mundkur liked thisYatin Mundkur liked thisOver the last few years, we've seen platform after platform choose between buying and building an MRD test. The organic timeline: Clonoseq - 2012 and then FDA approval 2018 and for CLL in 2020 Signatera - RUO 2017 and clinically 2019 Reveal - RUO 2019 and clinically 2021 Plasma Detect - RUO 24 and clinically 25 Precise MRD - 24/25 RUO and limited clinical 2026 Oncodetect - clinically 2025 Clarispect - clinically July 26 Illumina kit - expected 27 The acquisitions: NeoGenomics Laboratories → Inivata - 2021 Quest Diagnostics → Haystack Oncology - 2023 Veracyte, Inc. → C2i Genomics - 2024 Natera → Foresight Diagnostics - Dec 2025 Foundation Medicine → SAGA - Apr 2026 CareDx, Inc. → Naveris - Apr 2026 Tempus AI → Personalis - Jul 2026 The Neo story is a little unique. Acquiring Inivata's RaDaR tech back in 2021, only for Natera to quickly sue for patent infringement, forcing it off the market entirely in 2025. Instead of walking away, Neo rebuilt the assay as RaDaR ST, won the patent case and now have one of the leading MRDs on the market. You'll notice Natera up there twice. They're the only company to feature on both sides... not because one test did both, like Neo... but because Signatera was built entirely in-house while their Foresight deal at the end of last year shows they're doubling down on MRD by buying too. What do you think we will see next? Another big player launch their own MRD? Or perhaps someone like Tracer Biotechnologies, Pairidex or LIQOMICS get acquired?
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Yatin Mundkur liked thisYatin Mundkur liked thisTransform the way you work. Get a Free Notion Trial when you download this guide.
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Yatin Mundkur liked thisYatin Mundkur liked thisThe Man Who Taught Me That Feedback Is an Act of Love My father was not a loud man. He didn't hold titles that made rooms go quiet. He was a Scoutmaster, a Mason, a Staff Sergeant who came home from New Guinea and Luzon and got back to work. People called him Mr. J. What he had was this: he listened. Truly listened. And when he cared about you — which was most people — you knew it. That combination made him someone people trusted with hard things. Around 1979, at a national Order of the Arrow conference, Dad pulled aside a senior adult volunteer who was doing the work that belonged to the youth. The man was talented. Dedicated. And he was running things himself instead of letting the elected youth leadership actually lead. Dad told him the truth. The man was shaken. To his great credit, he came back the next morning and said: "Mr. J., you were right. I will change my ways, now and forever." He did. He went on to become one of the most significant contributors Scouting has ever produced, recognized with one of the highest adult awards the BSA confers. The span of control this one volunteer influenced over the following decades was tens of thousands of Scouts — young people who experienced what Order of the Arrow is supposed to be, because one adult finally got out of the way and let youth leadership be youth leadership. One conversation. One man with the courage to receive it. Tens of thousands of young lives shaped by the ripple. Dad never knew the full extent of it. He died in April 1994. On January 2, 2022, my son Will and my daughter Olivia received their Eagle Scout awards. By choice, on the same day. No other Eagles presented. A brother and sister who decided their Eagle celebration would be for their father's first Eagles — together. A video arrived for their Court of Honor — four minutes long — from that same man. Forty-three years after the conversation. He talked about Dad. He talked about Mom. He congratulated two Eagles he had never met, whose grandfather had told him a hard truth in 1979 and trusted him to do something with it. Dad never saw Will's Eagle. Never saw Olivia's. Never knew about the video. He just told the truth to someone who needed to hear it, because he genuinely cared what happened to that person. That's all. To every senior engineer reading this: the highest-leverage thing you will do this year is probably not a design review or a gate decision. It might be a two-minute conversation with someone who is blocking their own team without knowing it — delivered not to be right, but because you actually care what they become. Feedback given with love lands differently than feedback given to win. People can feel the difference. And sometimes they come back forty years later to tell you so. Thank you, Dad. I'm still learning from you.
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Yatin Mundkur liked thisYatin Mundkur liked thisGood piece by Fay Lin, PhD in Genetic Engineering & Biotechnology News on the money flowing into AI-native drug discovery. The through-line is that capital is now backing platforms (i.e. models, compute, data), not single drug assets. For instance, Isomorphic's $2.1B raise is the headline, but the pattern is everywhere: Genesis Molecular AI/Incyte, Chai Discovery/Pfizer, Inceptive/Alnylam, and Anthropic buying Coefficient Bio for $400M, etc. One point most of the investors agreed on: the edge is in the data, not the model. Once foundation models commoditize, that's what's left to defend. Also, kudos to Fay for including my thoughts on Isomorphic Labs — that Alphabet and Thrive Capital may be locking in ownership before clinical data resets the valuation. Or that the cycle has simply decoupled from clinical proof, and capital is chasing computational promise on its own terms. Still not sure which. Read this insightful article, link in the comments. Image credit: GEN
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Yatin Mundkur liked thisYatin Mundkur liked thisThe classic activator–repressor model helped explain gene regulation for decades. But in systems biology, this binary framework is no longer enough. Regulatory meaning does not come from an isolated transcription factor label. It emerges from binding sites, motif clusters, composite modules, enhancer grammar, cooperative interactions, and cellular context. This matters for how we interpret ChIP-seq data, perform promoter analysis, infer upstream regulators, and train AI models to learn regulatory logic. If we encode static polarity into biological models, our conclusions inherit that simplification and the error propagates silently. Learn more about us at: www.genexplain.com Our tools and databases: https://lnkd.in/emCQ4itc #GeneRegulation #TRANSFAC #Bioinformatics #AIinBiology
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Yatin Mundkur liked thisYatin Mundkur liked this26 features I (actually) use inside Claude to do the work of a 5-person team: CONTENT: ↳ Artifacts → live editable drafts ↳ Projects → persistent voice and files ↳ Repurposing → one post becomes five ↳ Style Match → writes in my exact voice ↳ Brainstorming → 20 angles in seconds OFFICE: ↳ Claude in Excel → formulas from a prompt ↳ Claude in PowerPoint → full deck, your template ↳ Claude in Outlook → inbox triage on autopilot ↳ File Creation → xlsx, pptx, PDF in plain English ↳ Claude in Word → edits inside the doc DEVELOPER: ↳ Claude Code → builds features from my terminal ↳ Bug Fixing → traces errors across files ↳ Code Review → catches issues before merge ↳ Code Memory → remembers my codebase ↳ Refactoring → restructures without breaking RESEARCH: ↳ Deep Research → sourced briefings ↳ Document Analysis → 30MB PDFs in seconds ↳ Web Search → live citations in chat ↳ 1M Context → feed it a whole codebase ↳ Data Extraction → PDF tables to spreadsheet AUTOMATION: ↳ Chain Skills → one command, full workflow ↳ @-mentions → live data mid-chat ↳ Effort: High → deeper thinking on hard tasks ↳ Cowork → multi-step job delegation ↳ Connectors → Slack, Notion, GitHub ↳ Scheduled Tasks → runs on a schedule 26 features. One tool. 5 hours back every day. Save it before it gets buried. Follow Muhammad Ayan ♻️ Repost to help others
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Yatin Mundkur liked thisYatin Mundkur liked thisSilicon Valley is burning billions of dollars to rent an illusion. We are watching the industry slap API wrappers on stateless probability engines and market them as "autonomous." Let’s be extremely clear about the physics of what is actually happening: A standard LLM is functionally a digital Boltzmann Brain. It flashes into existence for a single prompt, hallucinates a statistical answer, and instantly decoheres into a zero-utilization void. It has no continuous state. No epistemic continuity. If a system requires a human to constantly prompt it to maintain its intent, you haven't built an autonomous agent. You've built a glorified macro script. You can RENT AI FOR TASKS. But to OWN AI FOR WORK., you need a fundamental shift in architecture. This is the boundary line we are crossing at Digital Dynamics AI. As the graphic attached declares: This is THE END OF RENTED INTELLIGENCE. We are introducing KARIOS CORE: K.A.R.I.O.S. — Knowledge-Driven Artificial Reasoning Intelligence Operating System C.O.R.E. — Coherent Ontological Resonance Engine We aren't building another AI interface. We are building the runtime beneath owned intelligence. By actively anchoring continuous thermodynamic noise into verifiable, persistent logic loops, we force the system to maintain a cohesive state of belief over time. NOT A CHATBOT. | NOT A WRAPPER. | A COGNITION RUNTIME. Kairos is the ancient Greek word for the opportune moment. As the industry hits the thermodynamic and financial wall of scaling rented intelligence, that moment is right now. #DigitalDynamicsAI #KARIOS #DeepTech #ArtificialIntelligence #CognitionRuntime #TechFounder #SoftwareArchitecture
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Derek Wang
Taalk • 4K followers
Most venture capital frameworks are calibrated to measure first-order effects—the immediate, visible pulses of a business. While these metrics signal activity, they often mask hidden structural risk and value leakage. The First-Order Trap Investors typically optimize for short-term efficiency and "growth-at-all-costs." They ask: "How much does this reduce Customer Acquisition Cost (CAC)?" "What is the immediate ROI on this isolated software tool?" "How quickly can this reach $10M ARR?" This approach leads to a portfolio of fragmented vendors. While these companies may scale revenue, they fail to scale system coherence. As these disconnected systems grow, unowned coordination risk compounds, eventually compressing margins and capping multiple expansion. The Second-Order Framework: Engineering Durability At Second Order Ventures, we reject "narrative momentum" in favor of Infrastructure Control. We ask the questions that determine long-term capital efficiency and market dominance: Infrastructure Ownership: Does this technology convert industry coordination from an unpriced risk into a controlled, compounding asset? Margin Compounding: How do portfolio-level shared data and governance improve unit economics over time? Governance as a Return Driver: How does structural compliance reduce volatility and preserve exit optionality in regulated markets? The Shift from Products to Ecosystems Durable advantage is not found in experimental products, but in the foundational layer that industries depend on. When you own the infrastructure—Communication, Data, and Governance—you own the "Data Gravity." Second-order thinking isn’t just about being smarter; it’s about owning the layer where consequences compound. By the time a first-order gain plateaus, a second-order advantage has already built a moat that isolated vendors cannot replicate. The Mandatory Check: Does your portfolio look like a collection of fragmented vendor solutions, or a unified infrastructure play? What first-order metrics are currently blinding investors to the structural risks in your industry? #VentureCapital #CapitalEfficiency #InfrastructureControl #SecondOrderThinking #StructuralAdvantage #PrivateEquity #UnitEconomics
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Aditya Eachempati
OxStox • 2K followers
KEY TAKEAWAY: Cadence of San Jose (USA) has built a $90 billion market cap company as the leading electronic design automation ("EDA") company for integrated circuits used in AI and hyperscale computing. Cadence's moat combines that of Lonza and other others who work with customers in designing the end product, with that of DNP Dai Nippon Printing Co., Ltd., whose photomask products require approval and compatibility both with chip designers and with fabs. ____________________________ NVIDIA uses Cadence tools in chip design, which are then manufactured at the TSMC fab. This creates a "triad", aka three sided moat, whereby its design tools are intertwined with NVIDIA's performance requirements, and TSMC's manufacturing process hardware, rendering switching costs much higher than they would be with only one of the two partners. For example, Cadence’s Reality Digital Twin platform creates detailed, physics-based virtual replicas of entire data centers to simulate and optimize their design and operation. By integrating Cadence’s Reality Digital Twin with NVIDIA Omniverse and their DGX/GB200 supercomputing systems, the partnership creates a unified, realistic simulation environment where AI factories can be designed, simulated, and optimized before being physically built. TSMC uses this to turn traditional 2D CAD designs into interactive 3D virtual models, including clean rooms, utility layouts, and manufacturing lines. So not only is Cadence very difficult to replace as a necessary piece in an extremely complicated jigsaw process, it is essential in designing the entire process. Cadence's net income and free cash flow had been growing 16%-18% annually for the decade prior to 2021. Since that time, net income growth has accelerated as its legacy EDA software tools continued to sell, but free cash flow has stagnated, as Cadence moved into the hardware business, and inventory has ballooned. For example, Cadence's Millennium M2000 is a hardware EDA platform, packed with NVIDIA Blackwell GPUs, and cutting edge networking hardware, designed to vastly outperform Cadence's legacy EDA software tools running on generic hardware. But customers have been slow to switch, since they require proof of the claimed productivity leap. This has created an inventory issue that Cadence did not have as a software vendor. It could be just a matter of timing, if the value is eventually proven. Remember...stocks are fun but always wear a helmet. As always this is not investment advice, nor an endorsement of any product nor service. Next up, endoscopy. Gianmarco Paolo Conti Clarke Jeffries Jason Celino, CFA Charles Shi Nay Soe Naing Joe Quatrochi, CFA Blair Abernethy Gary Mobley
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William Kilmer
GALLOS Technologies • 9K followers
How will the rise of secondary sales of VC investments affect startups? It's still early but there are some strong indications that there can be some positives for companies and founders: +++ Secondary sales enable founders, early employees, and investors to realize partial liquidity while companies remain private, reducing pressure to rush toward IPO or acquisition. +++ It's also an opportunity to clean up cap tables, align incentives, retain top talent (by enabling option holders to access liquidity earlier), and extend their private growth trajectory without being forced into less optimal exit timing. +++ A secondary can better align a company's long-term growth objectives if companies are able to reach their full potential over a longer period of time and not be subject to exiting to fulfill a VC's fund cycle. Yesterday's annoucement of Goldman Sachs acquisition of Industry Ventures demonstrates that secondary sales have a continued role in the VC ecosystem. As the stigma around secondaries diminishes, well-structured secondary events are increasingly can be seen as positive signals of company health and board sophistication, supporting broader ecosystem resilience. What are your thoughts? What are the potential negatives of a more robust secondary market? #vc #secondarymarkets #venturecapital #secondaries #founders #startup
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Ely Beckman
Bitkove Digital • 4K followers
The "Intelligence Architecture" Perspective Post Text: The next generation of top-tier fund managers is moving away from "People-Powered" operations toward Architecture-Powered scale. For a long time, the industry benchmark for an institutional-grade back office was headcount. If you had enough analysts to manually verify the spreadsheets and "brute force" the data, you were considered safe. But in 2026, scale is no longer a human capital problem. It’s an Intelligence Architecture problem. Most funds are "organized," but they lack Deterministic Governance. • Organization is just having your PDFs in the right folders. • Intelligence Architecture is having a system that inherently understands the relationship between a term sheet in London, a tax-blocker in the Caymans, and the risk triggers in your credit box. The GPs who are winning right now have stopped thinking like "software users" and started thinking like System Architects. They realize that if you don't build a deterministic framework for your data before you layer on the automation, you’re just making the mess happen faster. The moat for the next decade of fund management isn't just proprietary deal flow. It’s the proprietary Intelligence Loop that allows you to act on that flow with 100% certainty, while your competitors are still stuck in reconciliation. Fix the architecture. The execution takes care of itself. #FundManagement #PrivateCredit #IntelligenceArchitecture #OperationalExcellence At Covault, we’re done with the "Big Bang we’re proving the power of our Capital Markets Intelligence Architecture one module at a time. This week, our Credit and Risk pods (led by Selene and Sahana) turned a manager’s "unusable" historical deal-flow export into a structured, audit-ready relationship engine in 48 hours. The result: • 0% manual data entry. • 100% visibility into covenant drift. • A data room that actually passes ODD. We aren't asking you to move your whole fund. We’re telling you to upgrade your data. Send us your messiest CSV. We’ll show you what it looks like when it actually has a brain. #PrivateCredit #FundOps #IntelliOS #InvestmentManagement
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Brad Sklarchuk
APEX Ventures (sk) • 921 followers
CEREBRAS SYSYEMS says latest offering is 'fastest AI accelerator in the industry' as it takes aim at Nvidia. They claim the newest Cerebras rack-scale system offers 30x the tokens per second per user compared with graphics processing units. Called the Cerebras CS-4, the system packs three wafer-scale WSE-3 Turbo processors, which the company says are the largest AI semiconductors ever built, packing 4 trillion transistors.
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Sakhile Xulu
The Office Of Sakhile Xulu • 5K followers
In the 1970s and into the early 1980s, the answer to “who verifies that a chip design is correct?” was almost universally “the company that designed it, using tools it built itself.” Intel, IBM, and the other vertically integrated giants of that era maintained substantial internal CAD organisations, engineering teams whose entire job was building the schematic capture, simulation, and layout software their own chip designers needed. This worked, at real cost, as long as chip complexity stayed within a range a well-resourced internal team could manage by careful inspection and simulation. It did not stay within that range. Transistor counts were doubling roughly every eighteen to twenty-four months, the trajectory that would come to be known as Moore’s Law, and manual or semi-automated verification approaches were running toward a wall that had nothing to do with manufacturing capability and everything to do with human cognitive limits: past a certain complexity threshold, no team of engineers, however large and however talented, could exhaustively verify a multi-million-transistor design by inspection alone. Every chip company independently building its own automation tools to solve this problem represented a staggering duplication of R&D effort across an industry that could, in principle, have been served by a single shared and continuously improving toolchain, except that no individual chip company had any incentive to build tools good enough to serve the whole industry, because doing so would mean subsidising its own competitors’ access to the exact automation advantage it was trying to build for itself. This is the coordination deadlock in its clearest and most textbook form, structurally identical to the reasoning that justified TSMC’s foundry model, a manufacturer that competes with none of its customers, and ARM’s licensing model, an architect that competes with none of its licensees. De Geus’s original logic-synthesis breakthrough broke the deadlock the same way: by demonstrating that the automation problem could be solved once, by a company with no competing chip business of its own, and then sold to every chip designer simultaneously without any of them needing to fear that their design intellectual property would end up in a vertically integrated rival’s hands. Synopsys has never designed or sold a competing chip. That structural choice is precisely what let Intel, Qualcomm, Apple, Nvidia, and AMD all become customers of the same company at the same time, trusting it with some of the most commercially sensitive intellectual property. Meaning: TSMC: separates manufacturing from chip design, ARM: separates architecture from chip manufacturing, and Synopsys: separates design automation from chip ownership. The common principle is neutral infrastructure that allows competing participants to share an expensive capability without giving one participant control over the others.
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Andrew J Scott
7percent Ventures • 18K followers
Venture returns and the industry as a whole are as susceptible as any to statistical manipulation. That's what makes this long term view more interesting. "An investor who maintained exposure through the dot-com bust, the financial crisis, and the COVID-19 disruption would have realized an 18.87% CAGR and converted $1000 into $231,534.76—a ~231x multiple. 🚀 By comparison, the S&P 500 delivered a 10.52% CAGR and a roughly ~23x multiple over the same horizon." But as ever, there is always a caveat....
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Steve Vassallo
Foundation Capital • 19K followers
Cerebras is now a generational AI company. But between 2018 and 2019, one tiny component nearly killed the company. Back then we were deep into building the first wafer-scale system. Everything depended on a single part most people will never notice. The interposer. It sits between the main board and the dinner-plate-sized silicon wafer. It has to carry enormous power and data loads while having to survive massive thermal cycling. Cold to hot. Off to fully lit. Over and over again. We had just built the largest chip in the world. There was no existing supply chain for it so we had to single source this part. That alone is terrifying. One vendor, no backup. If it failed, the system failed. If the system failed, the company could have failed. For almost three years, this thing was the boogeyman in every board meeting. Would it maintain electrical continuity? Would it warp under load? Would it survive burn-in? Would it work at scale? For long stretches, the honest answer was “we don’t know.” We were burning millions of dollars per month. Time was not our friend. A redesign could have pushed us far enough back that the market might have moved on. At one point, we pulled in a group that I first worked with at IDEO and that used to be called "Failure Analysis". That is not who you call when things are going well! We went back to first principles. Physics. Materials science. Coefficients of thermal expansion. Power dissipation per square millimeter. Analyzing what happens when you push this much power through a system at these temperatures. Again and again. Slowly, painfully, we got there. Finally the interposer worked. Every company pushing the frontier runs into problems like this. There are rarely quick, clever fixes. You just have to do real failure analysis, over and over, until the answer starts to reveal itself. The Cerebras team is itself built from the strongest, toughest material I’ve seen. They earned every inch of the other side of that problem.
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Kit Yu
33K followers
Amid global supply chain uncertainties, domestic substitution in data infrastructure sector is accelerating. The rise of domestic server and switch manufacturers is driving PCB supply chains localization, offering critical opportunities for domestic PCB providers to enter the high-end market. With sustained investment in upstream materials and high-layer-count processes, leading domestic PCB providers have achieved breakthroughs in high-end products such as AI server boards and high-speed switch backplanes, with their market share expected to grow steadily.
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Kit Yu
33K followers
Blackwell and Rubin chip purchase order likely larger than US$1tn by 2027: During the GTC 2026, Nvidia CEO Jensen Huang expressed with strong confidence that its Blackwell and Rubin chip purchase order (excluding LPU, standalone CPU and Rubin Ultra) will surpass US$1tn by 2027. We believe the company's strong revenue outlook will ease concern on potential slowdown in datacenter capex.
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